*Osteosarcoma in Greyhounds - genetic study by the Animal Hea

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filou007de
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*Osteosarcoma in Greyhounds - genetic study by the Animal Hea

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Osteosarcoma in Greyhounds - genetic study by the Animal Health Trust UK
http://www.galgonews.com/2012/09/i-am-f ... go+News%29

Osteosarcoma in Greyhounds - genetic study by the Animal Health Trust UK

Posted: 15 Sep 2012 07:28 PM PDT


Animal Health Trust logoThe Animal Health Trust, Newmarket, England, is doing a genetic study on Osteosarcoma in 8 breeds of dogs, including Greyhounds. Dr Mike Starkey is heading the research. I asked him if he had met Dr Couto of Ohio State University, who also studies greyhounds/galgos. He said 'I met Dr. Couto at a meeting in the United States earlier this year. He is part of a consortium of researchers working on osteosarcoma (in several breeds) in the US, and we are actively collaborating with another member of the US consortium. The study to identify genetic risk factors for US Greyhounds has been ongoing for some time - our initial objective is to evaluate if UK (in particular), but also non-US, Greyhounds are likely to share the same genetic risk factors for osteosarcoma as US Greyhounds

Dr Starkey describes his study.

The Greyhound osteosarcoma study is a relatively recent initiative. The basis of the studies to identify genetic risk factors for osteosarcoma in Greyhounds are relatively detailed surveys (using definitive data from clinical, histopathological and/or insurance databases) of the prevalence of osteosarcoma in different pedigree dog breeds that demonstrated that Greyhounds (amongst a number of large/giant breeds) have a higher risk of developing of osteosarcoma than ‘most other breeds’, suggesting the involvement of genetic risk factors.

I have not seen any detailed data on the prevalence of osteosarcoma in Spanish Galgos, and I am not aware of whether this is perceived to be an issue for the breed. However, if Galgo owners/breeders believe that osteosarcoma is a serious issue for the breed and will actively help us to collect samples, then we could certainly consider initiating a new study.

Genetic study on osteosarcoma in Greyhounds by the Animal Health Trust Oncology Research Group

The Animal Health Trust is a charity, and a research institute, that has been helping dogs, cats and horses for more than half a century. The Trust provides specialist veterinary clinical, diagnostic and surgical services, and is dedicated to the study of canine, equine and feline diseases. In collaboration with researchers in the United States, the Oncology Research Group at the Animal Health Trust is seeking to identify the one, or more, inherited gene alterations that are responsible for Greyhounds having an increased risk of developing osteosarcoma.

Osteosarcoma is the most common bone cancer of dogs. The tumours usually develop in the long bones of the legs close to the joints, such as by the stifle, or close to the shoulder joint. Early signs are lameness and pain. The tumour is extremely malignant and chemotherapy is usually required after surgery. About 40-60% of dogs that receive chemotherapy survive for 1 year, and half of these survive long term.

Osteosarcoma is associated with increasing height (and weight) and therefore the highest prevalence is in large and giant breeds. However, some families within these breeds are particularly affected, suggesting an inherited predisposition.

In 2003, researchers at the AHT examined the prevalence of osteosarcoma within a UK population of 130,684 dogs insured by a pet insurance company between June 1997 and May 1998. The researchers found that the Greyhound had a higher risk of developing osteosarcoma than the majority of the 17 other breeds for which osteosarcoma was reported, suggesting the involvement of genetic risk factors. An inherited susceptibility to developing osteosarcoma probably results from the combined effects of a number of gene alterations, each of which alone confers a low to moderate increase in risk.

In the long term, we hope that the research will lead to the development of DNA tests to identify dogs that have an increased risk of developing osteosarcoma, allowing breeders to take this into consideration in their breeding programmes. The identification of ‘osteosarcoma susceptibility genes’ will also increase understanding of how these tumours develop, thereby ultimately assisting the development of new treatments.

Greyhound owners can help the osteosarcoma study by submitting 2 types of sample:

1). Blood/cheek swab sample

If your dog (of any age) has a suspected osteosarcoma OR is at least 8 years
and has never had any type of cancer:

If your vet is taking a blood sample for a clinical reason and there is some blood left over, ask the vet to save a surplus sample (1-2ml) in an EDTA tube and send it to the AHT (address below)

OR

Contact the AHT (details below) to request a cheek swab kit (includes instructions). Collect some cells from the inside of your dog’s cheek and then send the cheek swabs to the AHT

2). Tumour sample

If your dog has a suspected osteosarcoma:

• Ask your vet to place a small piece (a 3-5mm cube) of the biopsy of the
suspected tumour (normally removed for diagnostic histopathology) in a
special preservative (‘RNAlater’) provided by the AHT upon request (details
below)

For any queries or more information about the project, please contact:
Dr. Mike Starkey [Tel: +44 (0)1638 555603; E-mail: mike.starkey@aht.org.uk

To submit a blood sample, or request a cheek swab kit and/or an RNAlater sample tube (for a tumour biopsy), please contact the Oncology Research Group [leave a message by telephoning +44 (0)1638 751000 extension 1214, or E-mail:
oncologyres@aht.org. uk

Animal Health Trust, Lanwades Park, Kentford, Newmarket, Suffolk, CB8 7UU, UK.

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Annette und die Chaostruppe


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vier-winde
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Re: Osteosarcoma in Greyhounds - genetic study by the Animal

Beitrag von vier-winde »

We received a call from a greyhound owner whose dog had been recently diagnosed with lung cancer. The more we spoke to the owner, the more we discovered that lung cancer was really the second part of the story. Their greyhound originally presented with osteosarcoma but lung cancer was then discovered on an x-ray. We kindly explained that the prognosis was nothing less than grim with the only option being euthanasia.

As it happens, this greyhound owner had gone from his regular vet to a surgeon who recommended immediate amputation of the dog's cancer-ridden leg. I discussed this with our Medical Director and, while we often disagree on things, we were completely in agreement on a course of action for this dog; possible short term pain medication followed by euthanasia, or immediate euthanasia. From our experience, we knew that every day this dog would feel worse. We both felt that the surgeon who suggested amputation made the poorest recommendation that a vet could make with no consideration whatsoever for the client or the dog.

The article below has been written to clarify our feelings in regards to greyhounds and osteosarcoma. We hope that everyone with a greyhound, or any pet, will read this because some day, when you are at your most vulnerable, you may be faced with an unscrupulous vet who will suggest potentially spending $10,000-$15,000 on a lost cause.

No one is perfect. Greyhounds, however, come pretty close. They are beautiful, elegant and gentle. They are the closest thing to a perfect dog. Unfortunately, their ability to develop bone cancer transcends that of almost all other breeds of dog. Osteosarcoma, or 'bone cancer', is an aggressive, life shortening cancer. There are options, but sadly, they often carry a poor prognosis and can be very expensive - think $5,000 to $15,000. It is important to be an advocate for your greyhound and educate yourself about both the prognosis and the financial investment before moving forward with a decision to treat or not to treat.

In general, if left untreated or with amputation only, a patient diagnosed with osteosarcoma, on average, may live up to three months from time of diagnosis. If treated aggressively (amputation with radiation and/or chemotherapy), the prognosis can be slightly better with a life expectancy rarely exceeding one year of life but usually less. Very rarely, a patient may live up to two years.

The typical presentation of a dog with bone cancer is limping and pain. If your greyhound is seven years old or older, don't be content to leave your vet with only an anti-inflammatory, such as Rimadyl. Have x-rays taken of the area in question. There is a typical presentation of how the bone will look when cancer is present. Most veterinarians will immediately recognize this making the diagnosis easier. To definitively diagnose, fine needle aspirates are performed which are easy, inexpensive and accurate. Biopsies can also be done, but they can be invasive, painful and pricey. Usually the radiographic presentation is so typical that fine needle aspirates and biopsies are unnecessary and we typically do not recommend them.
Mehr zum Thema unter http://www.ngap.org/bone-cancer-osteosa ... -y668.html
Liebe Grüße aus Glücksbüll

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Gerri
Beiträge: 534
Registriert: Di 22. Jul 2014, 11:34

Re: Osteosarcoma in Greyhounds - genetic study by the Animal Hea

Beitrag von Gerri »

Gerri hat geschrieben:
greycie hat geschrieben:We received a call from a greyhound owner whose dog had been recently diagnosed with lung cancer. The more we spoke to the owner, the more we discovered that lung cancer was really the second part of the story. Their greyhound originally presented with osteosarcoma but lung cancer was then discovered on an x-ray. We kindly explained that the prognosis was nothing less than grim with the only option being euthanasia.

As it happens, this greyhound owner had gone from his regular vet to a surgeon who recommended immediate amputation of the dog's cancer-ridden leg. I discussed this with our Medical Director and, while we often disagree on things, we were completely in agreement on a course of action for this dog; possible short term pain medication followed by euthanasia, or immediate euthanasia. From our experience, we knew that every day this dog would feel worse. We both felt that the surgeon who suggested amputation made the poorest recommendation that a vet could make with no consideration whatsoever for the client or the dog.

The article below has been written to clarify our feelings in regards to greyhounds and osteosarcoma. We hope that everyone with a greyhound, or any pet, will read this because some day, when you are at your most vulnerable, you may be faced with an unscrupulous vet who will suggest potentially spending $10,000-$15,000 on a lost cause.

No one is perfect. Greyhounds, however, come pretty close. They are beautiful, elegant and gentle. They are the closest thing to a perfect dog. Unfortunately, their ability to develop bone cancer transcends that of almost all other breeds of dog. Osteosarcoma, or 'bone cancer', is an aggressive, life shortening cancer. There are options, but sadly, they often carry a poor prognosis and can be very expensive - think $5,000 to $15,000. It is important to be an advocate for your greyhound and educate yourself about both the prognosis and the financial investment before moving forward with a decision to treat or not to treat.

In general, if left untreated or with amputation only, a patient diagnosed with osteosarcoma, on average, may live up to three months from time of diagnosis. If treated aggressively (amputation with radiation and/or chemotherapy), the prognosis can be slightly better with a life expectancy rarely exceeding one year of life but usually less. Very rarely, a patient may live up to two years.

The typical presentation of a dog with bone cancer is limping and pain. If your greyhound is seven years old or older, don't be content to leave your vet with only an anti-inflammatory, such as Rimadyl. Have x-rays taken of the area in question. There is a typical presentation of how the bone will look when cancer is present. Most veterinarians will immediately recognize this making the diagnosis easier. To definitively diagnose, fine needle aspirates are performed which are easy, inexpensive and accurate. Biopsies can also be done, but they can be invasive, painful and pricey. Usually the radiographic presentation is so typical that fine needle aspirates and biopsies are unnecessary and we typically do not recommend them.
Mehr zum Thema unter http://www.ngap.org/bone-cancer-osteosa ... -y668.html


Lungenkrebs bei Osteosarkom

Wir erhielten einen Anruf von einem Greyhound-Besitzer, dessen Hund kürzlich die Diagnose Lungenkrebs erhalten hatte. Je länger wir mit dem Besitzer sprachen, desto mehr stellte sich heraus, dass Lungenkrebs eigentlich nur die eine Seite der Medaille war. Sein Greyhound war zunächst mit Knochenkrebs diagnostiziert worden, der Lungenkrebs hingegen wurde dann auf einem Röntgenbild festgestellt. Behutsam erklärten wir, dass die Prognose äußerst schlecht aussah und die einzige Option das Einschläfern.

Doch der Greyhound-Besitzer war von seinem normalen Tierarzt zu einem Chirurgen gegangen, der die sofortige Amputation des vom Krebs befallenen Hundebeins. Ich diskutierte das mit unserem Medizinischen Leiter und – obschon wir uns häufig nicht einig sind – stimmten wie absolut darin überein, wie mit diesem Hund zu verfahren sei. Mögliche kurzzeitige Schmerzbehandlung gefolgt von Euthanasie, oder auch sofortige Einschläferung. Nach unseren Erfahrungen wussten wir, dass sich dieser Hund mit jedem Tag schlechter fühlen würde. Wir hatten beide den Eindruck, dass der zur sofortigen Amputation ratende Chirurg den denkbar schlechtesten Ratschlag gab, den ein Tierarzt geben könnte, da dies ohne Rücksichtnahme auf den Halter oder den Hund geschah.

Der unten stehende Artikel wurde geschrieben, um unseren Standpunkt bezüglich Greyhounds und Osteosarkomen auszudrücken. Wir hoffen, dass jeder mit einem Greyhound oder irgendeinem anderen Haustier, dies lesen wird, da Sie eines Tages, wenn Sie am verletzlichsten sind, möglicherweise mit einem skrupellosen Tierarzt konfrontiert sind, der Ihnen vorschlägt, möglicherweise bis zu 10.000-15.000$ für einen aussichtslosen Eingriff auszugeben.

Niemand ist perfekt. Greyhounds sind jedoch ziemlich nah dran. Sie sind wunderschön, elegant und sanft. Sie kommen einem perfekten Hund am nächsten. Unglücklicherweise übersteigt ihre Neigung, Knochenkrebs zu entwickeln, die von fast allen anderen Hunderassen. Das Osteosarkom, oder „Knochenkrebs“ ist ein aggressiver, das Leben verkürzender Krebs. Es gibt Möglichkeiten, aber leider haben sie meist eine düstere Prognose und können sehr kostspielig sein – rechnen Sie mit 5.000-15.000$. Es ist wichtig, für Ihren Greyhound zu sprechen und sich über die Prognose und den finanziellen Aufwand zu informieren, ehe Sie sich für oder gegen eine Behandlung entscheiden.

Im allgemeinen lebt ein Patient, der die Diagnose Osteosarkom erhalten hat, vom Zeitpunkt der Diagnose noch durchschnittlich bis zu drei Monate, wenn die Erkrankung unbehandelt verbleibt, oder nur amputiert wird. Wenn eine aggressive Behandlung erfolgt (Amputation mit Bestrahlung und/oder Chemotherapie), kann die Prognose etwas besser sein, mit einer Lebenserwartung, die kaum je ein Jahr übersteigt, meist jedoch weniger. Sehr selten kann ein Patient noch bis zu zwei Jahren leben.

Die typischen Symptome eines Hundes mit Knochenkrebs sind Humpeln und Schmerzen. Wenn Ihr Greyhound sieben Jahre oder älter ist, geben Sie sich nicht damit zufrieden, wenn Ihr Tierarzt lediglich anti-entzündlich behandelt, beispielsweise mit Rimadyl. Lassen Sie Röntgenbilder der betreffenden Region anfertigen. Es gibt eine typische Darstellung der Art und Weise, wie ein vom Krebs befallener Knochen aussieht. Die meisten Tierärzte werden dies sofort erkennen, was die Diagnose vereinfacht. Für eine sichere Diagnose wird eine Feinnadelaspirationsbiopsie gemacht, welche einfach, preiswert und genau ist. Biopsien können auch angefertigt werden, doch sie können invasiv, schmerzhaft und teuer sein. Normalerweise ist die radiografische Darstellung so typisch, dass Feinnadelaspirationsbiopsien und Biopsien unnötig sind und wir empfehlen sie normalerweise nicht.

Mehr zum Thema unter http://www.ngap.org/bone-cancer-osteosa ... -y668.html[/quote]

Übersetzt von Alina[/quote]
Viele Grüße von Alina mit Myka und Olivia

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